The best characterized of these paracrine intermediates are keratinocyte growth factor (KGF), which mediates GLP-2-induced colonic growth, and insulin-like growth factor-1 (IGF-1), which is essential for GLP-2s trophic effects in the small intestine (68)
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Danuglipron and orforglipron are nonpeptide oral GLP-1R agonists in development that have shown encouraging safety and efficacy in glycemic control among patients with T2DM [179]
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The Role of Weight Loss in Cholesterol Improvement Losing 5-10% of body weight triggers profound metabolic healing, including dramatic improvements in lipid profiles
Theyve been studied extensively in large clinical trials for safety, efficacy, and side effects
