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In certain embodiments, any otic formulation or composition described herein has less than about 60 colony forming units (CFU), has less than about 50 colony forming units, has less than about 40 colony forming units, has less than about 30 colony forming units of microbial agents per gram of formulation or composition

In an MS model, butyrate administration led to increased remyelination of neurons [261]

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Its primary research applications have focused on gut protection and musculoskeletal healing , but its mechanisms have direct relevance to eczema-damaged skin