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10.1016/j.biomaterials.2020.120190 74 ShenQ.-D.ZhuH.-Y.WangL.FanL.LiangJ.-H.CaoL.et al (2018a)

controls) were most striking in subjects with airflow limitation and were directly associated with lipid peroxidation and DNA oxidation byproducts, potentially indicative of airway structural damage (87, 88)

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These pharmacokinetic features, characterized by rapid clearance and short systemic exposure, further challenge their preclinical-to-clinical applicability

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