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Both medications have broadly similar side effect profiles dominated by GI symptoms nausea, vomiting, diarrhea, and constipation
GLP-1 also delays gastric emptying by inhibiting gastrointestinal (gut) motility via the ileal brake 4 , a feedback mechanism activated by unabsorbed dietary components in the ileum (portion of the small intestine)
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Tirzepatide , on the other hand, is a dual agonist