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Chang Y-L, Yang C-C, Deng J-F, Ger J, Tsai W-J, Wu M-L, Liaw H-C, Liaw S-J

Medications that block NET, including SNRIs like duloxetine and venlafaxine, tricyclic antidepressants, and atomoxetine, can worsen hyperadrenergic POTS by further preventing norepinephrine clearance

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Many patients find that morning dosing reduces lunch and afternoon snacking because the medication's effect coincides with when they're typically hungriest

This matters because IBS alone affects an estimated 1015% of adults worldwide

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