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Having an additional robust NADPH-independent back-up system for the two NADPH-dependent cytosolic disulfide reductase systems could provide survival advantages in cases of severe oxidative or toxic stresses

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22 The rapid emergence of drug-resistant microbes, and newly emerging infectious diseases, together with the ever- increasing number of difficult-to-treat persistent infections, have shown an urgent need for the development of effective preventive and therapeutic antibodies for infectious diseases

We compared survival outcomes between the two groups and observed a significant difference in overall survival (Fig

10.3390/ijms22158180 Int J Mol Sci