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Alkaabi, J

For instance, excessive activation of PARP1 in response to chronic DNA damage and inflammation accelerates features of aging

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No human clinical safety or efficacy data currently exist [6]

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According to still another embodiment of the present invention, the peptide Ac-Nle-cyc/o(- Asp-His-D-Phe-Arg-Trp-Lys)-OH is used for the manufacture of a medicament for treatment by multiple agent therapy with a PDE-5 inhibitor for sexual dysfunction, wherein the amount of each of the peptide Ac-Nle-cyc/o(-Asp-His-D-Phe-Arg-Trp-Lys)-OH and the PDE-5 inhibitor is not sufficient, if administered as monotherapy, to independently initiate the desired pharmacological response in the patient