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The VPA -oxidation metabolite 2-en-VPA is another agent that can promote cerebral oedema when it accumulates in brain and plasma

Tang NL, Ganapathy V, Wu X, Hui J, Seth P, Yuen PM, Wanders RJ, Fok TF, Hjelm NM: Mutations of OCTN2, an organic cation/carnitine transporter, lead to deficient cellular carnitine uptake in primary carnitine deficiency

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This causes small local changes in the binding site and movements in the cytosolic cap of the protein that are generally associated with priming of the channel 27

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Franck Azobou (Cardiology Fellow at UT Southwestern) sat down with Dr