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The good news is that B12 is one of the safest vitamins, but there are a few things to know about high-dose supplements and when theyre actually necessary

10.1007/s13760-015-0427-y Acta Neurol

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However, the anion gap remained elevated in the 25 to 31 mEq/L range for the next 7 days while the urine organic acid screen was pending

Some endogenous neuropeptides do cross via saturable transport systems, and there is speculation that DSIP may do so, but this has not been rigorously demonstrated for exogenously administered peripheral DSIP in humans

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