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Butyrate regulates leptin expression through different signaling pathways in adipocytes

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Methods: In the Netherlands Epidemiology of Obesity study, a population-based prospective cohort study, liver fat content was assessed at baseline using proton magnetic resonance spectroscopy in middle-aged population with overweight

Nausea, vomiting, diarrhea, and constipation can all be caused by slowed gastric emptying

The trajectory is powered by three converging factors, namely higher type-2 diabetes incidence, escalating obesity prevalence, and cardiometabolic guideline revisions that elevate incretin agents to first-line status

Insulin resistance is the most potent pathogenic potentiator, which promotes a pro-inflammatory state, with increased lipolysis, de-novo lipogenesis and free-fatty acid flux