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Description

Reproductive toxicity studies of acetylcysteine in the rat given oral doses of acetylcysteine up to 1,000 mg/kg (5.2 times the human mucolytic dose) have also been reported in the literature

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Studies have indicated that high ethanol exposure may increase the level of APP and beta-site APP cleaving enzyme 1 (BACE1) thus significantly promoted A production both in vitro and in vivo [6]

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Oct 2013;154(4):761-767

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Serious adverse effects are rare in clinical trials

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doi: 10.1093/nar/gkx1090

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