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The HPA axis operates under the fundamental mechanism of negative feedback and assumes a pivotal function in eliciting the bodys stress response and governing various physiological processes, encompassing digestion, immune system functionality, and energy equilibrium (191)

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Moreover, a natural compound of the tetraterpene group from tomatoes, lycopene (10 mg/day, P.O for 2 months), was reported to significantly increase the ratio of serum TAC to MDA in patients with type 2 diabetes [149]

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Cyclophilin A is a proinflammatory cytokine that activates endothelial cells