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In a randomized, controlled study of 64 patients with chronic renal insufficiency with elevated body burden of lead and without diabetes, three months of CaNa 2 EDTA weekly infusions resulted in slowing or reversing degeneration in the chelation group

Ineffective clearance of apoptotic bodies might lead to secondary necrosis, culminating in the release of pro-inflammatory molecules and aggravating systemic chronic inflammation

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Experimental studies suggest that DSIP may interact with multiple signalling mechanisms, including NMDA receptorrelated pathways and MAPK-associated signalling cascades, with observed effects dependent on concentration, exposure duration, and experimental context