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Subsequently, adding a GLP1-RA can enhance cardiovascular protection and further renal benefits, particularly in patients with high cardiovascular risk or significant albuminuria

Why it is helpful: FDA-approved with established safety profile Specifically targets deep visceral belly fat Supports lean body composition Improves metabolic markers including triglycerides and cholesterol ratios Benefits patients with insulin resistance and metabolic syndrome Common side effects: Injection site reactions, joint pain, peripheral edema, and myalgia

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These drugs also reduce inflammation in the brain and result in weight loss

These improvements may contribute to reduced cardiovascular risk

Hepatol Res 47:12061211 Green JB, Bethel MA, Armstrong PW et al (2015) Effect of Sitagliptin on cardiovascular outcomes in type 2 diabetes