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In addition, it also reversed oxidative damage and neuroinflammation by reducing levels of pro-inflammatory cytokines such as IL-1, TNF-alpha, and IL-6 and inhibiting glial cell activation

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Paraxanthine (1,7-dimethylxanthine, PXN) is the main metabolite of CAF, accounting for 7072% of ingested CAF and 85% of the methylxanthine metabolic by-products (Stavric 1988)

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found that oxidative stress in the synovium can promote glycolysis, which may help to accelerate the mechanism of inflammation (Balogh et al., 2018)

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