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(STEP-1 Trial, NEJM 2021) The STEP 5 two-year trial found no new risks emerging over time

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Therefore, in this study we characterized the signaling profiles of endogenous agonists GIP(1-42) and GIP(1-30)NH 2 and the drug tirzepatide at two GIP receptor isoforms, wildtype and E354Q, for five signaling pathways potentially relevant to the physiological actions of GIP in metabolism

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