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Use a medical-grade insulated cooler with cold packs to keep the pen between 36F and 46F

If a dose is missed and fewer than 12 hours have elapsed since the usual time, it can still be administered

2026 Update: In the SURMOUNT-5 head-to-head trial, tirzepatide produced ~47% more weight loss than semaglutide over 72 weeks

Significant changes (red one fill, yellow the next) usually mean a formulation update

[26] [27] Never discontinue therapy without medical guidance, as abrupt cessation can lead to loss of glycemic control or weight regain

But if they are intolerable, or if you experience any of the more serious side effects, it's important to let your healthcare provider know