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A GLP-1 drug acts on the following areas of the body Brain: decreases appetite and food reward mechanisms, and reduces food chatter or preoccupation with food, as well as lowering neuroinflammation

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Although our point estimate may suggest a potential neutral or increased risk of MACE with combination therapy, this may reflect confounding by indication rather than a true association

Waisbren SE, Stefanatos AK, Kok TMY, Ozturk-Hismi B

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