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As a new uremic toxin and potential biomarker, TMAO is involved in changes in the heart-gut-kidney axis, including neuroendocrine activation, hemodynamic changes, alterations in gut microbiota, and intestinal congestion (Xiong et al., 2023)

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Graham ID, Jette N, Tetroe J, Robinson N, Milne S, Mitchell SL: Oral cobalamin remains medicine's best kept secret