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Low intestinal glutamine level and low glutaminase activity in Crohn's disease: a rational for glutamine supplementation

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Briefly, snap-frozen liver samples were weighed and homogenized in chloroform:methanol (2:1) solution, followed by the addition of saline and centrifugation at 10,000 rpm to achieve phase separation

A Phase 1 Study to Assess the Safety, Tolerability, and Pharmacokinetics of Multiple Escalating Oral Doses of PF-07081532 in Adults With Type 2 Diabetes Mellitus

Generally, TPMTdeficient patients (homozygous mutant) can be treated with 610% of the standard dose of thiopurines (Zhou, 2006)