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This dual affinity creates a unique pharmacological effect within the family: cardioprotection demonstrated in myocardial ischemia-reperfusion models with a 2540% reduction in infarct size, an effect preserved in GHS-R1a knockout animals but abolished in CD36 knockout animals (formal mechanistic evidence of the CD36-independent pathway)

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Bnsgi B, Lewis-Smith D, Pal E, Duff J, Griffin H, Pyle A, Mller JS, Rudas G, Aranyi Z, Lochmller H, Chinnery P, Horvath R

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Other subjects underwent a similar BB challenge test following oral administration of 250 mg of synthetic d 9 (methyl)-BB (also provided in Vegicap)

Glucose-dependent insulinotropic polypeptide prevents the progression of macrophage-driven atherosclerosis in diabetic apolipoprotein E-null mice