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About 42% of online pharmacies that sell semaglutide, the active ingredient in Novo Nordisks anti-obesity drug Wegovy, are illegal, operating without a valid license and selling medications without prescriptions, according to a study published Friday in JAMA Network Open

10.1155/2019/3642491 34 de PaulaA

STEP 1 Trial, NEJM 2021 In people with type 2 diabetes or prediabetes, semaglutide stimulates insulin secretion in a glucose-dependent manner meaning it only acts when blood sugar is elevated

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A new study from Lilly helps answer that question: among adults with obesity without diabetes, tirzepatide was associated with greater weight loss than semaglutide at six months, along with stronger improvements in several cardiometabolic measures