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It's particularly well-studied, has been on the market longer, and has a well-understood side effect profile

Theriogenology (2020) 148:10311

GIP, the second target activated by tirzepatide and Retatrutide, adds complementary effects on insulin secretion and fat metabolism while also influencing reward pathways through distinct mechanisms

Cell 178 , 275289 (2019)

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A more recent study found a disproportionate number of acute kidney injuries linked specifically to Ozempic and Wegovy compared to other GLP-1 drugs a finding that may strengthen claims for patients who developed kidney complications while on semaglutide-based medications