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We classify the functional characteristics of currently known paralogs into two distinct groups (Figure 25A): (1) paralogs that have lost metal coordinating residues and may or may not dispense of the need for metal altogether (Category 1), and (2) paralogs that are metal-promiscuous and require a metal for catalysis but may or may not retain function with Zn II (Category 2)

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To view a copy of this licence, visit About this article Cite this article ORegan, G., Plummer, Z., Christie, B.R

Most common side effects are manageable with medications, eye care, diet changes, or short breaks in treatment