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Clinical trials have demonstrated hemoglobin A1c reductions of approximately 2% in diabetes patients, with weight loss ranging from 7-11% in diabetes trials (SURPASS) and 15-21% in obesity trials (SURMOUNT), depending on the dose administered and patient population

2,5 DPP-4 inhibitors reduce post-prandial glucose excursions by around 3 mmol/L and basal glycaemia by around 1.01.5 mmol/L

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Additional research themes include immune balance and oxidative stress

Insulin levels during the glucose tolerance test were substantially lowered in the calorie-restricted mice and in mice treated with GLP-1MK-801 (Extended Data Fig