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Elevated PKM2 expression activates the transcription of HIF-1 and promotes the release of high mobility group box 1 (HMGB1) from activated macrophages, thereby amplifying sterile inflammation, particularly in sepsis-associated AKI, and enhancing TEC susceptibility to OS (Yang et al., 2014)
[11] Pyo HK, Yoo HG, Won CH, Lee SH, Kang YJ, Eun HC, Cho KH, Kim KH
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Jonklaas J, Bianco AC, Bauer AJ, et al
When weakened by chronic injury or internal disruption, it can partially or completely tear
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