Essential B Vitamins for MTHFR B9 (Folate) Form: 5-MTHF (methylfolate), NOT folic acid Dose: 400-800mcg daily minimum (up to 5mg for some conditions) Why: Bypasses MTHFR enzyme bottleneck Look for: Quatrefolic, Metafolin, or L-5-MTHF on labels B12 (Cobalamin) Form: Methylcobalamin OR hydroxocobalamin (avoid cyanocobalamin) Dose: 500-1000mcg daily minimum (up to 5000mcg for deficiency) Why: Essential cofactor for methylation, lowers homocysteine Choose methylcobalamin for: Direct methylation support Choose hydroxocobalamin for: Sensitive individuals, histamine issues B6 (Pyridoxine) Form: P5P (pyridoxal-5-phosphate), the active form Dose: 5-50mg daily, but will be highly individualised Why: Supports transsulfuration pathway, prevents homocysteine buildup Avoid: Regular pyridoxine HCl (requires conversion) B2 (Riboflavin) Form: Riboflavin or riboflavin-5-phosphate Dose: 10-100mg daily (higher doses for C677T homozygous) Why: Required cofactor for MTHFR enzyme function Benefit: Can improve MTHFR enzyme efficiency up to 50% Supporting Nutrients Magnesium Zinc Choline or TMG (Betaine) How to Choose a B12 Supplement for MTHFR Look for methylcobalamin or hydroxocobalamin Avoid cyanocobalamin Check for fillers or artificial folic acid Sublingual/ spray forms often absorb better Frequently Asked Questions About B12 and MTHFR Which form of B12 is best for MTHFR
20+20=40 30cc syringe / 10mL BAC Water / 10mg VIAL= 1000 Units 20mcg= 1Unit are you sure your dose is only 20 mcg, not 200 mcg
The same mechanism that makes TRT effective at raising testosterone levels also suppresses your bodys natural production
For example, FDA labeling for cyanocobalamin injection includes contraindications (such as hypersensitivity) and important warnings (see the FDA prescribing information for cyanocobalamin injection )
Another commenter suggested simplifying the HRSN policy, because it could lead to finger pointing between specialists and PCPs
But...the fact remains that if you have symptoms which could be due to B12 deficency, then more frequent injections are required - thought the UK prescribing guidelines don't appear flexible enough to actually enable this (after loading doses and neurological regime - if needed - the only options seem to be eight weekly or three monthly
