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70 No effects on risk were noted for semaglutide, lixisenatide, exenatide, nor albiglutide in which relative risks were not significant

The weight regain patterns observed with other agonists suggest that maintaining lifestyle changes during the treatment period is crucial for sustaining results after discontinuation

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Unfortunately, due to its high cytotoxicity, aminoguanidine cannot be used in clinical practice 83

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Interestingly, a recent study by the Mandrup laboratory has shown that exposure to high glucose (25 mM) elicits a biphasic response in INS-1E cells 43