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The increases in omega-3 FA in the brain and other tissues were plotted against the increases in plasma BDNF or erythrocyte omega-3 of each animal to determine the Pearson correlation coefficients (Graphpad Prism 8.0)

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Many patients report that symptoms are most pronounced in the 1-3 days following their weekly injection, then gradually improve as the week progresses

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coli 0111:B4, catalog number L2630, MilliporeSigma, Burlington, MA) and 0.1 ml of PBS or 2 M peptide in PBS were applied to a 1-cm 2 sterile piece of gauze secured to the hair-free back skin with a bio-occlusive dressing (Tegaderm)

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