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Serious adverse events were defined by the study of Rubino, Wadden and ONeil et al., as life threatening, results in death, requires hospitalization or prolongation of existing hospitalization, results in persistent disability/incapacity, congenital anomaly/birth defect, important medical event (may jeopardize subject or may require medical/surgical intervention to prevent outcomes listed previously but may not be immediately life-threatening or result in death or hospitalization), as preventing daily activities by Wilding et al

Deviations shorten shelf life and can reduce efficacy or safety

Chem Biol Interact 340:109448

This minimizes waste from the 28-day use window

Having your alcohol swabs, medication, and sharps container ready can reduce any anxiety about the process