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GLP-1 agonists were originally designed as a treatment for people with type 2 diabetes

The retina is especially vulnerable to oxidative stress due to its high oxygen exposure and high concentration of polyunsaturated fatty acids

Clarke R, Birks J, Nexo E, et al

Some participants reported nausea and diarrhea as the most common side effects, but those were generally mild and easily managed

We had previously included a 30% probability of approval and $4 billion in probability-weighted sales by 2033 in our Amgen valuation

It is stable in gastric acid and can be taken orally, which gives it a practical edge for gut applications