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Epigenetic modifications have been reported to induce a series of changes in gene expression and protein levels that result in mitochondrial abnormalities and neuronal apoptosis and lead to PD (Ndayisaba et al., 2019)

systemic administration may cause off-target effects (e.g., promoting tumorigenesis via global ferroptosis inhibition) or insufficient renal tissue penetration, which has not been addressed in preclinical studies

Safety and side effects Glutathione is generally safe

Its mechanism of action is incredibly sensitive

Prescribing an unapproved new drug outside a trial is technically illegal under the FDCA (aside from narrow compassionate-use exceptions)

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