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Further supporting the role of LA as a zonulin inhibitor, one study found that LA treatment reduced both rearrangement and redistribution of actin and the tight junction-associated protein zonula occludens-1 (ZO-1) in Caco-2 brush-border-expressing cells that were exposed to AT-1002, a synthetic hexamer peptide derived from the active Zot fragment that has been shown to increase tight junction permeability (24)
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According to public FDA communications, the agency has resolved the tirzepatide drug shortage, ended enforcement discretion periods for compounding pharmacies, and sent warning letters to multiple telehealth companies regarding compounded GLP-1 sales and marketing practices
