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Conformational Search and ECD Spectra Simulation The conformational search of GHRPs was performed by the conformerrotamer sampling tool (CREST) [25, 26] with the GFN2xTB method [27] and implicit solvation considered by the analytical linearized PoissonBoltzmann (ALPB) model [28]

Sample Volume Limitations Many projects are constrained by scarce or precious material (e.g., small tissue biopsies, limited plasma volume, rare cell populations)

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An additional eleven healthy individuals, matched for age and gender with the HACE patients, were recruited as healthy controls (Ctr)

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