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Science translational medicine 4, 141190

10.1038/ijo.2017.77 Int

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Apremilast, an oral phosphodiesterase 4 (PDE4) inhibitor, in patients with moderate to severe plaque psoriasis: results of a phase III, randomized, controlled trial (Efficacy and Safety Trial Evaluating the Effects of Apremilast in Psoriasis [ESTEEM] 1)

Duffy SJ, Gokee N, Holbrook M, Huang A, Frei B, Keany JFJ

Across the PIONEER trials around 1523% of patients experienced nausea with orally administered semaglutide 14 mg, and approximately 715% of patients on 14 mg orally administered semaglutide discontinued the trial