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Osmotic laxatives such as polyethylene glycol 3350 (MiraLax)

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The microbiomes of healthy controls in both prospective and cross-sectional cohort studies differ widely (that is, there is a great deal of interindividual variability), and what is described as a healthy microbiome in one study can vary tremendously from that in another study, particularly when comparing cohorts across very different environments 39

Temporarily, yes

1 A systematic review by the Endocrinology and Nutrition Unit, University of Pavia, concluded that Berberine positively influences gut microbiota and cholesterol absorption at doses around 300-500 mg/day, supporting its role as an adjunct in obesity and diabetes care