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Study 1: STEP-1 Trial (Obesity) Published in The New England Journal of Medicine , the STEP-1 trial found that adults with obesity or overweight who received weekly semaglutide injections lost an average of about 15% of their body weight over 68 weeks, compared with just 2.4% in the placebo group

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Regulatory hurdles: Approval for novel indications (Alzheimers, neurodegenerative diseases) requires very high bar: long follow-ups, clinically meaningful endpoints, safety

Sahin IH, Lin Y, Yothers G, Lucas PC, Deming D, George TJ, Kopetz S , Lieu CH, Dasari A

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