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Ipamorelin's selectivity stimulating GH without substantially raising cortisol or prolactin further distinguishes it from both HGH and older GHRPs

Because these are separate receptor populations using different second messenger systems, simultaneous activation produces additive-to-synergistic GH pulse amplification without receptor competition or off-target hormone effects

Unlike growth hormone therapies that stimulate pituitary secretion, IGF-1 LR3 directly activates cellular growth and repair pathways

Tesamorelin Sermorelin vs

DOI: 10.1007/s00213-021-05986-6

This combination leverages the strengths of both pathways while keeping side effects manageable