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Both formulations are licensed in the UK by the Medicines and Healthcare products Regulatory Agency (MHRA)

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These structural changes extend the drugs activity in the body, enabling less frequent dosing while maintaining its therapeutic effect

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[8] Patients with significant alcohol intake or thiamine deficiency also require precaution: chronic heavy alcohol use can deplete thiamine (vitamin B) and taking ALA in the setting of thiamine deficiency has been associated with serious health risks (including a condition resembling Wernickes encephalopathy)