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For researchers tracking the GLP-1 class, it represents the current frontier of what a single peptide can do for energy balance and is the closest thing the literature has to a 'maximum-effect' incretin reference

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It is not known if Wegovy will cause thyroid tumors or a type of thyroid cancer called medullary thyroid carcinoma (MTC) in people Do not use Wegovy if you or any of your family have ever had a type of thyroid cancer called medullary thyroid carcinoma (MTC) or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) Do not use Wegovy if: you or any of your family have ever had a type of thyroid cancer called medullary thyroid carcinoma (MTC) or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) you have had a serious allergic reaction to semaglutide or any of the ingredients in Wegovy injection or Wegovy tablets

Semaglutide and a drug called liraglutide (approved in 2014) both mimic the gut hormone GLP-1

Among those was reportedly Retatrutide UK, which had a score of 4.4 on Trustpilot, according to a Guardian investigation