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McCoy RG, Herrin J, Swarna KS, et al

They also interact with certain pain medications and can worsen post-operative nausea

anemia, fatigue)

Commonly reported GLP-1 adverse effectsincluding nausea, vomiting, constipation, and abdominal discomfortsubstantially overlap with symptoms of an IBD flare, which may complicate safety monitoring and clinical assessment

Peptides also have fewer and more subdued side effects

Retatrutide is an investigational drug, currently only available through legitimate clinical trials, with Phase 3 trials concluding in 2026