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Evening dosing before bed means these effects occur during sleep, when they're least disruptive

W., Lim, D

Robbins TW, Everitt BJ (1992)

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In this context, Van Hoecke et al screened a zebrafish model of ALS and identified Epha4, a receptor in the ephrin axonal repellent system, as a modifier of the disease phenotype in fish, rodents and humans[39]