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Notably, only one hGM group (O15) acquired the TMA/TMAO-producing ability from its donor, whereas the other three hGM groups had undetectable plasma d9-TMA and d9-TMAO (Fig

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14 Sochovsky, N

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LINZESS should be taken 1 : On an empty stomach and at least 30 minutes prior to a meal At approximately the same time each day Clinical considerations 1 Duration of use is not limited Dosing adjustments for patients with renal or hepatic impairment are not required No drug-drug interactions are anticipated Negligible systemic availability INDICATIONS AND USAGE LINZESS (linaclotide) is indicated for the treatment of: irritable bowel syndrome with constipation (IBS-C) in adults and pediatric patients 7 years of age and older chronic idiopathic constipation (CIC) in adults functional constipation (FC) in pediatric patients 6 years of age and older IMPORTANT SAFETY INFORMATION WARNING: RISK OF SERIOUS DEHYDRATION IN PEDIATRIC PATIENTS LESS THAN 2 YEARS OF AGE LINZESS is contraindicated in patients less than 2 years of age