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Its biological functions include: (1) adjusting gene performance (May et al., 1998

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15 In addition to the generation of reactive oxygen species (ROS), a series of events, including inflammation, calcification, elastin crosslinking, and the accumulation of collagens, occur, leading to increased arterial stiffness overall

191 For example, SIRT1 activity is stimulated under conditions that elevate cellular NAD levels due to decreased energy status, such as fasting, caloric restriction, and physical exercise