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This process is also typically accompanied by the inhibition of glutathione peroxidase 4 (GPX4) and glutathione (GSH) systems, which normally eliminate lipid peroxides [7, 8]

2.3 Metabolic pathway and statistical analyses Quantitative enrichment analysis of 258 detected metabolites was utilized for pathway analysis employing the web-based MetaboAnalyst 2.0 software (Xia and Wishart 2011)

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Inhibition of ROS by GSH or its analogs has been reported to block HIV replication, whereas increased intracellular GSH levels have been shown to enhance African swine fever virus replication 156,157 , indicating that the effect of GSH on viral replication varies according to the virus type

Next to NAD + precursors, modulation of NAD + -consuming enzymes showed promising results

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