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This review explores the mechanisms, clinical development, and therapeutic potential of these novel agents, excluding already approved drugs like liraglutide, semaglutide, and tirzepatide

Additive cardiovascular effects haven't been studied

GLP-1 receptor agonist liraglutide inhibits the proliferation and migration of thyroid cancer cells

In India, obesity is defined at a lower Body Mass Index (BMI 25 kg/m) compared to global standards due to higher metabolic risks among Asian populations

While much has been published on cellular expression of GPCRs, including the GLP-1R, when evaluating the validity of such data it is key to consider the methodologies applied [e.g., immunohistochemistry (IHC), in situ hybridization (ISH), polymerase chain reaction (PCR), in situ ligand binding (ISBL)]

At least 25 transmitters have been suggested to play key roles in feeding behaviour [54]