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Es verstrkt zudem die Synthese von Glykosaminoglykanen und Decorin, Schlsselmoleklen fr die Integritt der Gewebematrix

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Thiamine deficiency decreased the activity of TPPK [189] and was implicated in decreased hepatic levels of TPP with normal levels of thiamine in STZ diabetic rats [190].Within mitochondria TPP is slowly hydrolyzed to TMP by phosphatases which may leave the mitochondria via the same transporter

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