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Nutrients, 15 (24)

found mitochondrial transcription factor A (TFAM, a key regulatory factor in mtDNA transcription and replication) deficiency and mitochondrial stress would cause the leakage of mtDNA into the cytoplasm, activating the cGAS-STING axis and initiating type I IFN response (81)

In some embodiments, the initial administration is of a particular formulation and the subsequent administration is of a different formulation or active pharmaceutical ingredient

suppresses the growth of hepatocellular carcinoma through endoplasmic reticulum stress-mediated autophagy and apoptosis