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N Engl J Med 326:22, 1992 The effect of impaired glucagon suppression on plasma glycemia is dependent on insulin Glucagon Glucagon Insulin Non-diabetic Diabetic HGP Glucose Glucose HGP Non-diabetic Diabetic AJP 277:E283;1999 Placebo Exenatide 0.10 g/kg sc 0 60 120 180 Time (min) Exenatide or placebo Exenatide Reduces Postprandial Glucagon Secretion in Patients With Type 2 Diabetes Meal 200 150 Plasma Glucagon (ng/L) 100 50 0 N = 20.Mean (SE)
Br J Nutr 2016;115:466-479
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Unlike some other peptides, it has a selective action on increasing growth hormone secretion, minimizing unwanted side effects
Improved insulin sensitivity may promote more efficient glucose uptake by skeletal muscle
Each requires different volume calculations for the same milligram dose
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