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Adult presentation has been reported in two sisters (62 and 56 years) with normal cognition, late-onset (mid-40s), and slowly progressive cerebellar ataxia, visual impairment, optic atrophy, proximal weakness, and partial Complex II deficiency in skeletal muscle [133]

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The primary mechanism is therefore identical to Sermorelin (GHRH 1-29) and CJC-1295 (tetra-substituted analog), but pharmacokinetics differ: approximately 8-minute plasma half-life for Tesamorelin via SC route (FDA Egrifta SV label) versus 10-15 min for Sermorelin and 6-8 days for CJC-1295 DAC

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Replenza conveniently delivers the essential vitamins and minerals that commonly get depleted on GLP-1 programs